KLM is set to resume operations between London City Airport and Amsterdam Schiphol on July 13.
The route will re-launch as a single daily service, with frequency increases expected as demand for travel returns, it said.
It will be operated by KLM subsidiary, KLM Cityhopper using an Embraer 190 aircraft carrying 100 passengers.
GM for UK & Ireland Benedicte Duval said: “After this challenging period, we are delighted to be able to resume operations from central London. Our partnership with London City Airport has been a huge success since we first launched the route in February 2016.
“Pre-Covid, we were operating up to nine flights a day so we look forward to increasing capacity in line with demand over the coming months.”